Bipolar Disorder vs Depression: Key Differences
Why misdiagnosis happens and how to tell them apart.
Major depressive disorder and bipolar disorder can look very similar during low phases. The critical difference is the presence of mania or hypomania in bipolar disorder—periods of elevated mood, increased energy, and impulsive behavior.

What Is Bipolar Disorder?
Bipolar disorder involves cycling between depressive episodes and manic/hypomanic episodes. There are two main types:
- Bipolar I: At least one full manic episode, usually with depressive episodes.
- Bipolar II: At least one major depressive episode and one hypomanic episode, but no full mania.
Signs of Mania or Hypomania
- Abnormally elevated, expansive, or irritable mood
- Decreased need for sleep without feeling tired
- Racing thoughts and rapid speech
- Increased goal-directed activity or restlessness
- Impulsive or risky behavior (spending, sex, substance use)
- Inflated self-esteem or grandiosity
Why Misdiagnosis Matters
Antidepressants prescribed without a mood stabilizer can trigger mania in people with undiagnosed bipolar disorder. That is why screening for a history of mania is essential before starting antidepressant therapy.
The Mood Disorder Questionnaire (MDQ)
The MDQ is a widely used screening tool for bipolar spectrum disorder. It asks about lifetime history of manic/hypomanic symptoms and whether they clustered together in time.
Take the free MDQ bipolar screening test.
Book a telemedicine consultation or lab review with Dr. Taimoor Asghar.