Drug Half-Life Calculator

Calculates drug elimination half-life from volume of distribution and clearance, or from measured concentrations over time.

Calculate from PK parameters or from measured levels

L

Required for Vd/CL method

L/hr

Required for Vd/CL method

mcg/mL

Required for two-concentration method

hours
mcg/mL
hours

Enter values and click Calculate to see results.

References

  1. Volume of Distribution - StatPearls — NCBI Bookshelf (2023). https://www.ncbi.nlm.nih.gov/books/NBK545280/
  2. Clearance and Elimination - Anaestheasier — Anaestheasier.com (2025). https://www.anaestheasier.com/clearance-and-volume-of-distribution/
  3. Drug Half-life Explained: Calculator, Variables & Examples — Drugs.com (2025). https://www.drugs.com/article/drug-half-life.html