Vancomycin AUC/MIC Dosing

Vancomycin dosing and monitoring based on AUC/MIC target of 400-600 mg*h/L using first-order pharmacokinetic equations (trapezoidal method) or Bayesian approaches.

kg

Use actual body weight for vancomycin dosing

years
mg/dL
inches
mcg/mL

Drawn within 30 min before next dose at steady state

mcg/mL

Drawn 1-2 hours after end of infusion at steady state

hours

Typical vancomycin infusion time 1-2 hours

hours
mg

For AUC estimation from steady-state levels

mcg/mL

MIC by broth microdilution. Target AUC/MIC 400-600.

Enter values and click Calculate to see results.

References

  1. Vancomycin area under the curve/minimum inhibitory concentration — PMC (2023). https://pmc.ncbi.nlm.nih.gov/articles/PMC9716452/
  2. Optimizing Vancomycin Therapy: A Review of AUC Calculation Techniques — Contagion Live (2026). https://www.contagionlive.com/view/optimizing-vancomycin-therapy-a-review-of-auc-calculation-techniques
  3. Predicting the AUC for First Dose Vancomycin Using First-Order Pharmacokinetic Equations — PMC (2023). https://pmc.ncbi.nlm.nih.gov/articles/PMC10135334/
  4. 2020 Vancomycin Therapeutic Monitoring Guidelines (Rybak et al.) — IDSA/SIDP/PIDS (2020). https://academic.oup.com/cid/article/69/8/1361/5498432