Aminoglycoside PK Dosing

Pharmacokinetic dosing for aminoglycosides (gentamicin, tobramycin, amikacin) using Hartford extended-interval nomogram or traditional Sawchuk-Zaske pharmacokinetic methods.

Select the aminoglycoside agent to dose

Extended interval uses Hartford/Urban-Craig nomogram; traditional uses Sawchuk-Zaske PK method

kg

Use actual body weight unless underweight

inches

Used to calculate ideal body weight

Used for ideal body weight calculation

mL/min

Estimate using Cockcroft-Gault equation

mcg/mL

Required for Sawchuk-Zaske dose adjustment

mcg/mL

Required for Sawchuk-Zaske dose adjustment

mcg/mL

Level drawn 6-14 hours after first dose for nomogram plotting

hours

Time from start of infusion when random level was drawn

Enter values and click Calculate to see results.

References

  1. Nicolau DP et al. Experience with a once-daily aminoglycoside program administered to 2,184 adult patients — Antimicrob Agents Chemother (1995). https://pmc.ncbi.nlm.nih.gov/articles/PMC163878/
  2. Urban AW, Craig WA. Daily dosage of aminoglycosides — Curr Clin Top Infect Dis (1997). https://pubmed.ncbi.nlm.nih.gov/9403522/
  3. Aminoglycoside Dosing Calculator - ClinCalc — ClinCalc.com (2024). https://clincalc.com/aminoglycoside/
  4. Sarubbi FA, Hull JH. Amikacin serum concentrations — Ann Intern Med (1978). https://pubmed.ncbi.nlm.nih.gov/692863/