Digoxin Dosing

Calculates digoxin loading and maintenance doses using Jelliffe total body stores method or Jusko/Koup pharmacokinetic method with Koda-Kimble clearance estimation.

Age *

years

Adult patients only

Weight *

Use ideal body weight for digoxin dosing

Height *

inches

Used to calculate ideal body weight

Sex *

Used for IBW and Cockcroft-Gault calculations

Serum Creatinine *

mg/dL

Stable value over past 5 days preferred

Indication *

A-fib typically requires higher target concentrations than CHF

Dosage Form *

Bioavailability differs by route: IV=1, capsules=0.95, elixir=0.8, tablets=0.75

CHF Severity (if applicable)

Moderate-severe CHF reduces nonrenal clearance

Interacting Drugs

These drugs reduce digoxin clearance or volume of distribution

Measured Digoxin Level (for adjustment)

ng/mL

For maintenance dose adjustment at steady state

Current Maintenance Dose

mcg/day

Required for dose adjustment calculations

Enter values and click Calculate to see results.

References

Jelliffe RW. An improved method of digoxin therapy — Ann Intern Med (1971). https://pubmed.ncbi.nlm.nih.gov/5425676/
Koup JR, Jusko WJ, Elwood CM, et al. Digoxin pharmacokinetics: relation to renal function — Clin Pharmacol Ther (1975). https://pubmed.ncbi.nlm.nih.gov/507944/
Digoxin formulas - RXkinetics — RXkinetics.com (2024). https://www.rxkinetics.com/kin_help/hlp_digoxin_formulas.htm
Digoxin Dosing - GlobalRPh — GlobalRPh (2018). https://globalrph.com/digoxin-dosing/