Phenytoin TDM

Phenytoin pharmacokinetic dosing and Winter-Tozer corrected total concentration for hypoalbuminemia. Includes loading dose and maintenance dose calculations.

kg

Use ideal body weight unless obese

inches

Used to calculate ideal body weight

mcg/mL
g/dL

Normal albumin ~3.5-5 g/dL

ESRD patients need different Winter-Tozer coefficient

mg/day

For maintenance dose adjustment

mcg/mL

Therapeutic total range 10-20 mcg/mL

Enter values and click Calculate to see results.

References

  1. Predictive Performance of the Winter-Tozer and Derivative Equations for Estimating Free Phenytoin Concentration — PMC (2016). https://pmc.ncbi.nlm.nih.gov/articles/PMC5008422/
  2. Phenytoin Loading Dose Calculator - ClinCalc — ClinCalc.com (2018). https://clincalc.com/Phenytoin/LoadingDose.aspx
  3. Phenytoin (Dilantin) Correction Calculator - ClinCalc — ClinCalc.com (2018). https://clincalc.com/Phenytoin/Correction.aspx
  4. Phenytoin Dosing Calculator And Analysis - GlobalRPh — GlobalRPh (2017). https://globalrph.com/medcalcs/phenytoin-dosing-calculator-and-analysis/