Lithium Carbonate Dosing

Lithium dosing calculator using pharmacokinetic methods (Winter, Yukawa, Zetin) with creatinine clearance-based clearance estimation. Therapeutic range 0.6-1.2 mEq/L.

Age *

years

Sex *

Actual Body Weight *

Height *

inches

Serum Creatinine *

mg/dL

Target Lithium Level *

mEq/L

Acute mania: 0.8-1.2; Maintenance: 0.6-1.0; Prophylaxis depression: 0.4-0.8

Desired Dosing Interval *

Most commonly dosed twice daily

Formulation *

Bioavailability: IR ~1.0, ER ~0.85-0.9

Measured Lithium Level (for adjustment)

mEq/L

Drawn 12 hours after evening dose for standard monitoring

Current Daily Dose (for adjustment)

mg/day

Lithium carbonate 300 mg = 8.12 mEq lithium

Enter values and click Calculate to see results.

References

Lithium - StatPearls — NCBI Bookshelf (2024). https://www.ncbi.nlm.nih.gov/books/NBK519062/
Lithium Pharmacokinetic Information and Dosing Calculations — PKineticDrugDosing.com (2024). https://pkineticdrugdosing.com/documents/lithium.html
Calculation of Lithium Clearance for Clinical use Based on Renal Excretion in Japanese Patients — GraphyOnline IJCPP (2016). https://www.graphyonline.com/archives/IJCPP/2016/IJCPP-107/
Lithium Dosage Guide + Max Dose, Adjustments — Drugs.com (2025). https://www.drugs.com/dosage/lithium.html