Ceftriaxone Pediatric Dosing
Broad-spectrum cephalosporin dosing for meningitis, pneumonia, and serious infections in children.
Weight in kilograms
Severity and type of infection
Age in months
⚠️ Warnings & Contraindications
- Contraindicated in neonates with hyperbilirubinemia (displaces bilirubin from albumin)
- Do NOT mix with calcium-containing solutions (precipitation risk)
- Do NOT administer with IV calcium in neonates
- May cause biliary pseudolithiasis (sludging) - usually reversible
- Cross-allergy with penicillins approximately 5-10%
- May cause diarrhea and antibiotic-associated colitis
ℹ️ Clinical Notes
Available as 1g and 2g vials for IV/IM. Can be given once daily due to long half-life. For CAP in infants, some evidence supports 20 mg/kg BID for <1 year and 30 mg/kg BID for >1 year.
References
- Optimal Dosing of Ceftriaxone in Infants - PMC - PMC (2020)
- Ceftriaxone pediatric dosing - FDA/Neofax (2024)
Medical Disclaimer
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