Gentamicin Pediatric Dosing
Aminoglycoside antibiotic dosing for serious Gram-negative infections and neonatal sepsis in children.
Weight in kilograms
Age in months
Gestational age at birth (for neonates)
Clinical indication
⚠️ Warnings & Contraindications
- NEPHROTOXICITY: Monitor renal function (SCr, BUN, urine output) daily
- OTOTOXICITY: Irreversible vestibular/cochlear damage possible
- Once-daily dosing (extended interval) may be less toxic than divided dosing
- Therapeutic drug monitoring is essential
- Avoid concurrent nephrotoxins (vancomycin, amphotericin, contrast dye)
- Neonates have immature renal function and require longer intervals
- Dose reduction in renal impairment essential
ℹ️ Clinical Notes
IV/IM administration only. Once-daily dosing (5-7.5 mg/kg) is preferred in children due to concentration-dependent killing and reduced toxicity. Extended interval TDM: peak 20-30 mcg/mL, undetectable trough at 8-12 hours.
References
- Simplified Dosing Regimens for Gentamicin in Neonatal Sepsis - PMC (2021)
- Evaluation of Dosing Guidelines for Gentamicin - PMC (2015)
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